Grapeseed Extract Studies

2006/05/01 - Beneficial Effects of a Novel IH636 Grape Seed Proanthocyanidin Extract in the Treatment of Chronic Pancreatitis Oxygen-derived free radicals mediate tissue damage in acute and chronic pancreatitis. The addition of a commercially available IH636 grape seed proanthocyanidin extract (commercially known as ActiVin) to their treatment regimen led to a reduction in the frequency and intensity of abdominal pain as well as resolution of vomiting in 1 patient.

2004/12/22 - Animal Study Shows Grape Seed Extract May Protect Brain Health-food activists have long touted the value of taking grape seed extract. However, there has been little or no scientific evidence of the molecular basis for its benefits. Now, researchers at the University of Alabama at Birmingham (UAB) report the first direct evidence that the popular dietary supplement affects specific proteins in healthy brains in ways that may protect against future age-related dementia.

2003/02/27 - Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Free radicals and oxidative stress play a crucial role in the pathophysiology of a broad spectrum of cardiovascular diseases including congestive heart failure, valvular heart disease, cardiomyopathy, hypertrophy, atherosclerosis and ischemic heart disease.

2002/11/20 - Grape Seed Proanthocyanidins Prevent Plasma Postprandial Oxidative Stress in Humans The present study was designed to investigate the effect of supplementing a meal with grape seed proanthocyanidins (the main phenolic antioxidant of red wine) on plasma postprandial oxidative stress.

2002/03/20 - Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis This study evaluated whether a new generation antioxidant Activin derived from the grape seed proanthocyanidins, could reduce the induction of the adhesion molecules as a result of inflammatory response in the plasma of systemic sclerosis (SSc) patients.

2000/09/01 - Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. Hypercholesterolemia, a significant cardiovascular risk factor, is prevalent in the American population. We conclude that a combination of Cr and GSE can decrease total cholesterol and LDL levels significantly.